Physicochemical properties that control protein aggregation also determine whether a protein is retained or released from necrotic cells
Amyloidogenic protein aggregation impairs cell function and is a hallmark of many chronic degenerative disorders.Protein aggregation is also a major event during acute injury; however, unlike amyloidogenesis, the process of injury-induced protein aggregation remains largely undefined.To provide this insight, we profiled the insoluble proteome of se